What is Fasoracetam?
Fasoracetam was discovered by Japanese pharmaceutical company Nippon Shinyaku in the 1990s. Fasoracetam is a nootropic that is in the racetam family. Racetams are all modified from one parent compound, Piracetam, and is a class of drugs that can bind to receptors in the central nervous system. Other racetams include piracetam, aniracetam, oxiracetam, phenylpiracetam.
Fasoracetam is a nootropic that can be supplemented to enhance cognitive function. Most notably, it is currently being examined as a treatment for ADHD. This compound may have anxiolytic and mood-enhancing effects.
The chemical name of Fasoracetam is (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one. The difference between fasoracetam and the other racetams is the acetamide group on the 5 position of the 2-Pyrrolidone ring.
What does it do?
Currently, in humans, the evidence is inconclusive and the benefits of fasoracetam are largely anecdotal. Additionally, it is not FDA approved in the U.S.
Mechanism of Action
- Increases release of acetylcholine from cerebral cortex as well as increases the uptake of choline (a nutrient needed to make acetylcholine)
- Increases the number of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) receptors in the cortex
- Activates glutamate receptors (glutamate is an excitatory neurotransmitter)
Fasoracetam is currently being studied for attention deficit hyperactivity disorder (ADHD) after having failed to show that it improved vascular dementia in clinical trials.
Research with Fasoracetam in adolescents with ADHD are being studied in a phase II/III clinical trial. Fasoracetam activates glutamate receptor NFC-1 and has cholinergic and GABAb enhancing effects. Glutamate receptors influence how sensitive neurons are to excitatory signals. In this study, fasoracetam was used to treat adolescents who carried a gene called mGluR, a genetic variant.
This study found that by studying this drug on adolescents with this particular genetic variant, they can pinpoint how this drug works on individuals with this gene. Global rating scales such as the vanderbilt scales showed significant clinical improvement in ADHD symptoms. At least 100mg twice a day was the dosage required for a significant response.
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Focus, concentration, memory, mood
Fasoracetam has been reported to help with motivation, memory protection as well as have anti-anxiety effects which is typical within the racetam family.
It promotes calmness, relaxation and a focus state of mind which may be from the GABA upregulation in the brain. In addition, there is evidence of neuroprotective effects. In mice studies, it was found to prevent memory disturbances similarly to other members of the racetam family.
A promising benefit of this drug is the antidepressant and anxiolytic effects. In mice studies who were conditioned to be “helpless” showed that the racetam had strong antidepressant effects. More interestingly, these effects were just as potent as some SSRIs without the side effects (like MAO interactions).
Users report that they feel a wave of calmness as well as feel more driven to complete tasks such as studying and taking exams.
One user reported that his “high-level conceptualization was less distracting” and he could “get to the essence of things easier without worrying about my decisions”. But then after two weeks, he began to develop “brain zaps” when falling asleep which were similar to what he experienced from withdrawing on SSRIs.
Another user reported that it is “the most stable, predictable, clean nootropic” he’s ever taken.
For some individuals, fasoracetam had no noticeable effects which they had experienced similarly with other racetams.
How to take
10mg-30mg with meals, once or twice daily
Caution in elderly individuals because of the potential for kidney impairment which can slow down the elimination of this compound
Fasoracetam side effects:
There are little known side effects of this drug. However, this does not mean that there are no side effects. There just isn’t enough clinical data to draw conclusions as of yet. Anecdotally, users report that they felt heavy sedation while taking large doses of this drug.
Where to buy?
Trustworthy vendors include purenootropics and nootropics depot.
What is the oral bioavailability?
Fasoracetam appears to peak in 1.5-2 hours in humans and has a short half-life. Animal model half-life: 3 hours for monkeys, 2.1 hours for dogs, 0.67 for rats.
Fasoracetam vs Phenibut?
Phenibut is a nootropic similar to fasoracetam in that is also a nootropic. Phenibut is a central nervous system depressant with anti-anxiety and stimulant effects. It has been used to treat insomnia and anxiety. This compound is structurally similar to the neurotransmitter y-aminobutyric acid (GABA) and may act similarly to y-hydroxybutyrate (GHB) and baclofen. At low doses, it mildly increases dopamine concentration in the brain. Phenibut can be used recreationally to create a euphoric mood and has addiction, dependence and withdrawal effects. Most notably, tolerance is built quickly with this compound.
Anecdotally, individuals take fasoracetam for phenibut rebound and withdrawal. While there are success stories of withdrawing off phenibut with this compound, it is largely unstudied and not validated. The general consensus is to taper phenibut slowly over many days.
Bacopa is a natural herb used in ayurvedic medicine for anxiolytic effects and has a number of benefits: learn more here