Best brain supplements: A review of Noopept

Best smart pills or brain supplements noopept

Don’t listen to the person who has the answers; listen to the person who has the questions.

Albert Einstein

Nootropics and Limitless Pills

Ever seen the movie Limitless with Bradley Cooper? The premise of the movie is a “limitless pill”, which supercharges the brains of who ever takes it. Struggling after losing his job and rejected by his girlfriend, Eddie (Cooper) takes a “limitless pill” which allows him to acquire the mental IQ of a modern-day Einstein and elevate him to the top of the financial world where he gains the attention of a business tycoon.

Are nootropics “limitless pills”?

Sorry, to burst your bubble but nootropics are the very watered down version of the limitless pill, at least for now. Research is still in the preliminary state and although their effects are still to be determined, nootropics seem promising as a brain supplement. Nootropics are currently not legally used to treat medical conditions and are marketed as supplemental or vitamins for that extra boost of mental clarity, focus, and enhancement.

Nootropic is Greek for “Mind-Bending”

Nootropics are brain supplements or smart pills that are an emerging field since the 1970s. The word “nootropic” stems from the Greek words for “mind” and “to bend or turn”. In 2015, the global sales of these drugs exceeded 1 billion dollars and has only been increasing since then.

Cognitive enhancers are becoming extremely popular due to the easy accessibility of purchases through the internet and mainstream markets like Amazon.

These brain supplements may improve cognitive function, more specifically memory, motivation and creativity.

Particularly popular Nootropics include piracetam, modafinil, phenibut and Noopept.

In addition, these smart brain pills are not yet completely regulated by the DEA since they are considered supplements.

However, the fight against regulating these supplements is far from over. The U.S. DEA attempted to control a psychoactive drug called Kratom, a drug that produces similar effects to opioids. Due to a huge public backlash, the DEA rescinded their efforts for now.

What is Noopept?

Noopept, aka N-phenylacetyl-L-prolylglycine ethyl ester is a psychostimulatory smart pill and helps to promote cognitive health and memory. It is currently being sold in Russia to help prevent age-related cognitive decline. Noopept is quickly gaining popularity in the nootropic world; it is the new and improved piracetam and much less expensive.

It was first synthesized in 1996 and has been alluded as one of the best bang-for-your-buck smart pills.

Studies in Moscow found that Noopept improved alpha/beta1 EEG brain wave patterns which are important in external focus and intellectual activity.

Noopept reviews are found anecdotally all over the web and the brain supplement is particularly popular on Reddit pertaining to nootropics.

Reddit users report improved overall memory, focus, sleep, and even one user reported that Noopept cured him/her of a “weird gait”

More excitingly, users report that their senses are enhanced; they report that colors seem to jump more, music is more enjoyable and touching their cat’s fur is softer than usual.

However, with great power, comes great responsibility. There are concerning anecdotal reports that some users experienced short term memory loss after using Noopept.

More so, studies have shown that in megadoses, Noopept can cause brain fog.

In addition, a common problem was raised by the nootropic online community noting that finding the perfect dosing regimen can be extremely difficult since there is not enough research conducted on a larger population.

It is evident that valid research is needed in the realm of nootropics since they are simply obtainable and available to anyone with access to the internet and extra cash on hand.

Here are 10 things you should know about Noopept:

1. Noopept is considered a smart pill and can be purchased online since it is marketed as a brain supplement. Noopept is similar to piracetam but is 1000-fold as potent as piracetam.

Noopept appears to have a similar mechanism of action when researchers looked at the brain wave patterns when studying these two drugs. Even more so, they found that you can take a lot less Noopept than piracetam and Noopept still has longer effects due to its potency.

2. Scientists discovered two mechanisms of Noopept that they theorized can enhance memory function.

3. It might be better to take Noopept one hour prior to studying or starting learning tasks.

4. 20mg daily of Noopept improved memory in individuals who suffered a stroke or a traumatic brain injury.

5. Noopept restored spatial memory in mice models of Alzheimer’s disease.

7. Noopept performed better than Piracetam in stroke patients; patients had less anxiety, irritability, fatigue with Noopept after ~2 months.

6. Researchers are still unsure if Noopept for cognitive enhancement will work for healthy humans or animals.

8. Noopept has anxiolytic effects or anti-anxiety effects.

9. The recommended dosage is 10mg-30mg daily.

10. Noopept is well-tolerated and minimal side effects are reported.

The worse side effects include headaches or brain fog at mega doses.

P.S. Dosing Regimen Tips

With any new supplements or smart pills, it is pertinent to always start on the lower side of the dosing regimen.

For any drugs, mindfulness in dosing matters: always start low and go slow!

The Takeaway

Noopept is a nootropic, a smart pill that is being studied on cognitive enhancement and neurologic repair after traumatic brain injuries and strokes.

Anecdotally, Noopept may improve cognition and memory and possibly increase the sense of smell, taste, and touch.

However, scientific research has yet to find conclusive evidence on the cognitive enhancing abilities of Noopept in healthy individuals.

Read about brain supplements for ADHD


  1. “Noopept,”, published on 5 October 2014, last updated on 14 June 2018,
  2. Medium. (2019). Noopept — A Poor Man’s Cognitive Enhancing Drug – Jonathan Roseland – Medium. [online] Available at: [Accessed 14 Feb. 2019].
  3. Kondratenko, R., Derevyagin, V. and Skrebitsky, V. Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. Neurosci Lett. 2010; 476(2): 70-73
  4. Vakhitova, Y. et al. Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept. Acta Naturae. 2016; 8(10: 82-89
  5. Vorobyov, V., Kovalev, G., and Sengpiel, F. Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors. Brain Research Bulletin. 2011; 85(3): 123-132.

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